Effect of telomere length on telomeric gene expression
نویسندگان
چکیده
منابع مشابه
Effect of telomere length on telomeric gene expression.
Telomeres gradually shorten as human somatic cells divide and a correlation has been observed between the average telomere length and cell senescence. It has been proposed that the genes responsible for cell senescence are located near the telomere and are activated when telomere length reaches a critical point. This is consistent with evidence from Saccharomyces cerevisiae, in which genes are ...
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Background Polycystic ovary syndrome (PCOS) is one of the reasons of infertility in women with chronic anovulation. Ovulation process is tightly regulated by molecular mechanisms controlling proliferation/differentiation of cells. Telomeres, TTAGGG tandem repeats, are transcribed into a non coding RNA, named TERRA. Recent studies suggest that TERRA sustain several important functions at chromos...
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A commentary on TERRA expression levels do not correlate with telomere length and radiation sensitivity in human cancer cell lines We read with great interest the Research Article by Smirnova et al. (1) in which sets of isogenic subclones isolated from human cancer cell lines were used to investigate the impact of telomere length on telomeric repeat-containing RNA (TERRA) expression. The first ...
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Progressive telomere shortening occurs with division of normal human cells, and eventually leads to replicative senescence. The mechanism by which the shortened telomeres cause growth arrest is largely unknown. Transcriptional silencing of genes adjacent to telomeres, also called telomere position effect, has been hypothesized as a possible mechanism of telomere-mediated senescence. However, th...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1996
ISSN: 1362-4962
DOI: 10.1093/nar/24.21.4336